Ultrastructural Alterations Caused by Cytostatic Sugar-Alcohol Derivatives1

a, 5th Intern. Congr. Chemotherapy, Vienna, June 26—July 1, 1967, pp. 475-476, 1967.6. Börzsönyi,M., Varga, L., Lapis, K., and Várterész,V. H3-Thymidine Incorporation into NK/Ly Ascites Lymphoma CellsFollowing Treatment with DBD(l,6-dibromo-l,6-dideoxydulcitol). In: Abstracta, 5th Intern. Congr. Chemotherapy,Vienna, June 26-July 1, pp. 503-504, 1967. 7. Brandes, D., Role of Lysosomes and Labilizers in Tumor CellRegression Following Chemotherapy and Radiation Therapy.In: Abstracts of Papers, 9th Intern. Cancer Congr. Tokyo,Oct. 23-29, 1966, p. 371, 1966. 8. Brandes, D., and Anton, E. Potentiation of the AntitumorEffect of Cytoxan (Cyclophosphamide) against Mice Mammary Tumors and Leukemia by Lysosomal Labilizers. In:Abstracts of Papers, 9th Intern. Cancer Congr. Tokyo. Oct.23-29, 1966. p. 374, 1966. 9. Brandes, D„Sloan, K. W„Anton, Elsa, and Bloedorn, F. TheEffect of X-Irradiation on the Lysosomes of Mouse MammaryGland Carcinomas. Cancer Res., 27: 731-746, 1967.10. Brookes, P., and Lawley, P. D. The Reaction of Monoand Difunctional Alkylating Agents with Nucleic Acids. Biochem.J., 80: 496-503, 1961. 11. Bucher, O. Die Amitose der tierischen und menschlichen Zelle.In: L. V. Heilbrunn and F. Weber (eds.), Handbuch derProtoplasmaforschung. Protoplasmatologia, Band 6/E/l, pp.1-159. Austria: Springer Verlag, 1959. 12. BÃ1⁄4ck,R. C. Lamellae in the Spindle of Mitotic Cells ofWalker 256 Carcinoma. J. Biophys. Biochem. Cytol., 11: 227236, 1961.13. Castoldi, G. L., and Malacarne, P. Aspects cytochimiques etcytogénétiquesdu gigantisme cellulaire provoquépar les antimitotiques. Nouvelle Rev. Franc. Hématol.,4: 395-408, 1964. 14. Connors, T. A., Elson, L. A., and Léese,C. L. The Effect ofGlucose Pretreatment on the Antitumor Action of MannitolMyleran. Biochem. Pharmacol., 13: 963-968, 1964. 15. Connors, T. A., and Léese,C. L. Mannitol Myleran c., d.,In: Ann. Rept. Inst. Cancer Res. Exptl. Chemotherapy Brit.Cancer Camp., pp. 12-13, 1962.16. Csányi, E. Die Wirkung eines neuen Cytostaticums, des 1,6-Dibrom-l,6-didesoxy-d-mannits, auf die Hämopoese der Ratte.Arzneimittel-Forsch., 15: 198-204, 1963.17. Csányi, E. Die Wirkung des l,6-dibrom-l,6-didesoxy-D-Mannit(DBM) auf die Hämopoese von Ratte. In: Ungarische Phar-makotherapeutische Konferenz, Budapest, 1962, pp. 326-330. Akademischer Verlag, 1963.18. Csányi, E., Horváth, P., and Institoris, L. Die zytostatischeWirksamkeit der halogenen D-mannit-Derivate. In: Ungarische Krebstagung, Budapest, 1961, pp. 148-154. Akade mischer Verlag, 1962.19. Csányi, E., Horváth, P., Institoris, L. Tumorhemmende, häma-tologische Wirkungen des l,6-Dibrom-l,6-didesoxy-D-mannits.Arzneimittel-Forsch., 14: 670-673, 1964. 20. de Duve, C. Lysosomes and Chemotherapy. In: R. J. C. Harris(ed.), Biological Approaches to Cancer Chemotherapy, pp.101-112. London: Academic Press, 1961. 21. de Duve, C. The Lysosome Concept. In: A. V. S. Reuck andM. P. Cameron (eds.). Lysosomes, Ciba Foundation Symp.,pp. 1-35. London: J. & A. Churchill, Ltd., 1963. 22. de Duve, C. From Cytases to Lysosomes. Federation Proc.,»: 1045-1049, 1964. 23. de Duve, C., and Wattiaux, R. Functions of Lysosomes. Ann.Rev. Physiol., 28: 435-492, 1966.24. Eckhardt, S. Chroni« Myeloid Leukemia and Dibromomannitol Therapy. In: Abstracta, 5th. Intern. Congr. Chemotherapy, Vienna, 1967, June 26-July 1, pp. 893-894, 1967. 25. Eckhardt, S., and Seilei, C. The Effect of Chemotherapy onthe Chromosome Pattern of Leukocytes in Leukemic Patients. 1262CANCER RESEARCH VOL. 28 on May 11, 2017. © 1968 American Association for Cancer Research.cancerres.aacrjournals.orgDownloaded from Cytostatic Sugar-Alcohol Derivatives In: Abstracts of Papers, 9th Intern. Cancer Congr. Tokyo,Oct. 23-29, 1966, p. 639, 1966. 26. Eckhardt, S., Seilei, C., and Hartai, F. The Effect of MannitolMyleran (1,6-dimethansulfonoxy-D-mannitol) on Patients Suffering from Chronic Myeloid Leukemia. Orv. Hetilap, IOS:1987-1989, 1961. 27. Eckhardt, S., Seilei, C., Horváth, I. P., and Institoris, L. Effectof l,6-dibromo-l,6-dideoxy-D-mannitol on Chronic Granulo-cytic Leukemia. Cancer Chemotherapy Rept., 83: 57-61, 1963.28. Eckhardt, S., Seilei, C., Horváth, P., Institoris, L., Medgyesi,À.,Masszi, F., Hartai, F., and Hindy, I. The Effect of 1,6-dibromo-l,6-dideoxy-D-mannitol on Chronic Myeloid Leukemia. Orv. Hetilap, 106: 547-549, 1964. 29. Elson, L. A. Hematological Effects of the Alkylating Agents.Ann. N.Y. Acad. Sci., 68: 826-833, 1958. 30. Goldstein, A. Biostatistics. New York: Macmillan and Co.Ltd.; London: Collier Macmillan Ltd., 1964.31. Gordon, G. B., Miller, L. R., and Bensch, K. G. Studies on theIntracellular Digestive Process in Mammalian Tissue CultureCells. J. Cell Biol., 26: 41-55, 1965. 32. Haddow, A. Experimental and Clinical Aspects of the Actionof Various Carboxylic Acid Derivatives of the Aromatic Nitrogen Mustard Series. In: Ciba Foundation Symp. LeukemiaRes., pp. 196-204, London: J. & A. Churchill, Ltd., 1954.33. Haddow, A., Timmis, G. M., and Brown, S. S. Tumor-inhibiting Action of 1,6-Dimethanesulphonyl-D-mannitol. Nature, 182: 1164-1165, 1958. 34. Hidvégi,E. J., LÃ3nai, P., Holland, J., and Antoni, F. TheEffect of Mannitol-myleran and Two New Dibromohexitols on the Metabolic Activities of Nucleic Acids and Proteins.Biochem. Pharmacol., 16: 2143-2153, 1967. 35. Horváth, I. P. Classification of Biological Alkylating Agentson the Basis of Structure-Activity Correlations. In: Abstractsof Papers, 9th Intern. Cancer Congr. Tokyo, Oct. 23-29, 1966, p. 363, 1966.36. Horváth, I. P., and Institoris, L. Influence of the ChemicalStructure on the Biological Tendency of Cytostatic Compounds Related to Dibromomannitol. Part II. Mechanism ofAction. Arzneimittel-Forsch., 17: 149-155, 1967. 37. Hruban, Z., Spargo, B., Swift, H., Wissler, R. W., and Kleinfeld, R. G. Focal Cytoplasmic Degradation. Am. J. Pathol.,42: 657-683, 1963. 38. Institoris, L., Eckhardt, S., Horváth, I. P., and Seilei, C. Comparative Data on the Action Mechanism of 1,6-dibromo-1,6-dideoxy-D-mannitol and 1,5-Dimethan-sulfonoxy-n-butane.Arzneimittel-Forsch., 16: 45-50, 1966. 39. Institoris, L., and Horváth, I. P. Untersuchungen Ã1⁄4berZusammenhänge zwischen-a-w-Substitution und cytostatischer Aktivitätbei einigen Zuckeralkohol-Derivaten und bei 1,6-dibrom-1,6-didesoxy-D-mannit. Arzneimittel-Forsoh., 14: 668-670, 1964.40. Institoris, L., Horváth, I. P., and Csányi, E. Activité cytostatique de certains dérivéshalogà ̈nes de polyalcools. In: 2nd.Symp. Intern. Chimiothérapie Naples, 1961, Vol. 3, pp. 250262. Basel : Verlag S. Karger, 1963.41. Institoris, L. Horváth, I. P., and Csányi, E. Influence of theChemical Structure on the Biological Tendency of CytostaticCompounds Related to Dibromomannitol. Part I. Structure-activity Correlations. Arzneimittel-Forsch., 17: 145-149, 1967. 42. Kellner, B. Histological Changes and their Chronological Sequence Induced in Transplanted Tumours by Nitrogen Mustard, Mustard Gas and BCM (l,6-bis(/3-chloroaethylamino)-1,6-deoxy-d-mannite-dichlorhydrate). Acta. Morphol. Acad.Sci. Hung. 7: 215-235, 1956.43. Kellner, B. The Significance of Amitosis and MultinuclearCells in Tumour Growth. Acta Biol. Acad. Sci. Hung. 7: 1314, 1957.44. Kellner, B. l,6-Dibromo-l,6-dideoxy-dulcitol, a New Anti-tumoural Agent. In: Summaries of the Lectures. 4th Hungarian Coni. Therapy Pharmacol. Res. Budapest, 1966, pp.125-126, 1966.45. Kellner, B., and Németh, L. Biological Effect of 1,6-Di-methane-sulphonyl-D-mannitol in Animal Experiments. Brit.J. Cancer, 13: 469-476, 1959.46. Kellner, B., Németh,L., Horváth, P., and Institoris, L. 1,6-Dibromo-l,6-dideoxy-dulcitol: A New Antitumoural Agent,(Preliminary Report). Orv. Hetilap, 107: 737-738, 1966.47. Kellner, B., Németh,L., Horváth, I. P., and Institoris, L. 1,6-Dibromo-l,6-dideoxy-dulcitol: A New Antitumoural Agent.Nature, HIS: 402-403, 1967. 48. Kindred, J. E. The Blood Cells and Hemopoietic and OtherOrgans of Dogs Given Intravenous Injections of 2-Chloroethyl-vesicants. Arch. Pathol., 47: 378-398, 1949. 49. Koller, P. C. Comparative Effects of Alkylating Agents onCellular Morphology. Ann. N.Y. Acad. Sci., 68: 783-801, 1958. 50. Koller, P. C., and Casarini, A. Comparison of CytologicalEffects Induced by X-rays and Nitrogen Mustards. Brit. J.Cancer, 6: 173-185, 1952. 51. Lapis, K. Electron Microscopic Morphology of Induced CellDamages, (in Hungarian only). Morphol. IgazságÃ1⁄4.Orv.Szemle., 6: 273-280, 1966. 52. Lapis, K. Ultrastructural Study of the Effect of AntitumouralChemotherapeutic Agents, (in Hungarian only). Thesis ofD. Sc., Budapest, 1967.53. Lapis, K. Fine Structural Alterations Induced in Ascites Tumour Cells by Vincaleukoblastin. Acta Morphol. Acad. Sci.Hung., in press.54. Lapis, K., and Benedeczky, I. Electron-Microscopic Examina tion of the Alterations Produced by Different Chemotherapeutic Drugs in Tumour Cells. In: Summaries of the Lectures,4th Hungarian Conf. Therapy Pharmacol. Res. Budapest,1966, pp. 148-149, 1966.55. Lapis, K., and Benedeczky, I. Comparative Studies of Subcellular Alterations Caused by Different Chemotherapeuticsin Shay Tumour of Rats. In: Abstracts of Papers, 9th Intern.Cancer Congr., Tokyo, Oct. 23-29, 1966, p. 387, 1966. 56. Lapis, K., and Benedeczky, I. Electron Microscopic and Electron Histochemical Studies on NK/Ly Ascites Tumour Cellsafter Treatment with Vinblastin. In: Abstracta, 5th Intern.Congr. Chemotherapy, Vienna, 1967, Part 1, pp. 521-522, 1967. 57. Lapis, K., and Benedeczky, I. Electron Microscopical Studyof Shay's Chloroleukemia (in Hungarian with English and Russian Summaries). Magy. Onkol., 11: 94-105, 1967. 58. Lapis, K., and Benedeczky, I. Electron Microscopic Study ofthe Shay Chloroleukemia. Cancer Res., 27: 1544-1564, 1967. 59. Lapis, K., Benedeczky, I., and Bolla, K. Ultrastructural Alterations Induced by Alkylating Agent (R-74) in Tumour Cells.Acta Biol. Acad. Sci. Hung., 18: 303-322, 1967. 60. Lapis, K., and Mercer, E. H. An Electron Microscope Studyof NK Lymphoma Cells and the Changes Produced by TwoCytostatic Drugs. Cancer Res., S3: 678-681, 1963. 61. Lewis, W. H. Binucleate Cells and Giant Cells in Tissue Cultures and the Similarity of the Latter to the Giant Cells ofTuberculous Lesions. Tubercle London, 8: 317-330, 1927. 62. Lewis, W. H. The Formation of Giant Cells in Tissue Cultureand their Similarity to those in Tuberculous Lesions. Am.Rev. Tubero., 16: 616-628, 1927.